CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX WITH INHIBITORS
The structure was published by Matthews, T.P., Mchardy, T., Klair, S., et al., Garrett, M.D., Reader, J.C., and Collins, I., in 2010 in a paper entitled "Design and Evaluation of 3,6-Di(Hetero)Aryl Imidazo[1,2-A]Pyrazines as Inhibitors of Checkpoint and Other Kinases." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of SERINE/THREONINE-PROTEIN KINASE CHK1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN). The sample contained 289 residues which is < 90% of the natural sequence. Out of 289 residues 249 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: