2xe4 Summary

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Structure of Oligopeptidase B from Leishmania major

The structure was published by Mcluskey, K., Paterson, N.G., Bland, N.D., Isaacs, N.W., and Mottram, J.C., in 2010 in a paper entitled "Crystal Structure of Leishmania Major Oligopeptidase B Gives Insight Into the Enzymatic Properties of a Trypanosomatid Virulence Factor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.65 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely OLIGOPEPTIDASE B and ANTIPAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A OLIGOPEPTIDASE B Q4QHU7 (1-731) (Q4QHU7_LEIMA)search Leishmania majorsearch 100% 751 96%
B ANTIPAIN Not available
Actinobacteriasearch Not available 4 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q4QHU7 (1 - 731) OLIGOPEPTIDASE B Leishmania major

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q4QHU7) Rossmann foldsearch PF00326: Prolyl oligopeptidase familysearch, PF02897: Prolyl oligopeptidase, N-terminal beta-propeller domainsearch
B

Chain Molecule NORINE reference
BANTIPAINNOR00664

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q4QHU7) serine-type endopeptidase activitysearch serine-type peptidase activitysearch serine-type exopeptidase activitysearch oligopeptidase activitysearch hydrolase activitysearch proteolysissearch cytosolsearch

Chain InterPro annotation
A Peptidase S9, prolyl oligopeptidase, catalytic domainsearch Peptidase S9A, prolyl oligopeptidasesearch Peptidase S9, serine active sitesearch Peptidase S9A, N-terminal domainsearch Alpha/Beta hydrolase foldsearch
B