INHIBITORS OF JAK2 KINASE DOMAIN
The structure was published by Ioannidis, S., Lamb, M.L., Wang, T., et al., Ye, M., Huszar, D., and Zinda, M., in 2011 in a paper entitled "Discovery of 5-Chloro-N2-[(1S)-1-(5-Fluoropyrimidin-2-Yl) Ethyl]-N4-(5-Methyl-1H-Pyrazol-3-Yl)Pyrimidine-2,4-Diamine (Azd1480) as a Novel Inhibitor of the Jak/Stat Pathway" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.04 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of TYROSINE-PROTEIN KINASE JAK2.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: