2xa4 Summary



The structure was published by Ioannidis, S., Lamb, M.L., Wang, T., et al., Ye, M., Huszar, D., and Zinda, M., in 2011 in a paper entitled "Discovery of 5-Chloro-N2-[(1S)-1-(5-Fluoropyrimidin-2-Yl) Ethyl]-N4-(5-Methyl-1H-Pyrazol-3-Yl)Pyrimidine-2,4-Diamine (Azd1480) as a Novel Inhibitor of the Jak/Stat Pathway" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.04 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of TYROSINE-PROTEIN KINASE JAK2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYROSINE-PROTEIN KINASE JAK2 O60674 (835-1132) (JAK2_HUMAN)search Homo sapienssearch < 90% 298 93%
B TYROSINE-PROTEIN KINASE JAK2 O60674 (835-1132) (JAK2_HUMAN)search Homo sapienssearch < 90% 298 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O60674 (835 - 1132) TYROSINE-PROTEIN KINASE JAK2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (O60674) protein kinase activitysearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch