DISCOVERY OF A NOVEL CLASS OF TRIAZOLONES AS CHECKPOINT KINASE INHIBITORS - HIT TO LEAD EXPLORATION
The structure was published by Oza, V., Ashwell, S., Brassil, P., et al., White, A., Zabludoff, S., and Zheng, X., in 2010 in a paper entitled "Discovery of a Novel Class of Triazolones as Checkpoint Kinase Inhibitors-Hit to Lead Exploration." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.92 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of SERINE/THREONINE-PROTEIN KINASE CHK1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN). The sample contained 289 residues which is < 90% of the natural sequence. Out of 289 residues 257 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: