2x7t Summary

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STRUCTURES OF HUMAN CARBONIC ANHYDRASE II INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON-STEROIDAL INHIBITORS.

The structure was published by Cozier, G.E., Leese, M.P., Lloyd, M.D., et al., Thiyagarajan, N., Acharya, K.R., and Potter, B.V.L., in 2010 in a paper entitled "Structures of Human Carbonic Anhydrase II/Inhibitor Complexes Reveal a Second Binding Site for Steroidal and Non-Steroidal Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.89 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) plasma membranesearch extracellular spacesearch extracellular vesicular exosomesearch cytosolsearch apical part of cellsearch cytoplasmsearch axonsearch membranesearch microvillussearch basolateral plasma membranesearch positive regulation of dipeptide transmembrane transportsearch positive regulation of osteoclast differentiationsearch regulation of intracellular pHsearch response to pHsearch morphogenesis of an epitheliumsearch positive regulation of bone resorptionsearch regulation of anion transportsearch response to organic substancesearch kidney developmentsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch carbon dioxide transportsearch response to steroid hormonesearch bicarbonate transportsearch positive regulation of cellular pH reductionsearch angiotensin-activated signaling pathwaysearch response to estrogensearch response to zinc ionsearch secretionsearch one-carbon metabolic processsearch zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch