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Structure of human serine-arginine-rich protein-specific kinase 2 (SRPK2) bound to purvalanol B

X-ray diffraction
2.5Å resolution
PDB entry 2x7g coloured by chain, front view.
PDB entry 2x7g coloured by chain, side view.
PDB entry 2x7g coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SRSF protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 16425.85 Å2
Buried surface area: 3738.49 Å2
Dissociation area: 112.44 Å2
Dissociation energy (ΔGdiss): -2.95 kcal/mol
Dissociation entropy (TΔSdiss): -0.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-160255

Macromolecules

SRSF protein kinase 2
Chain: A
Length: 389 amino acids
Theoretical weight: 44.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P78362 (Residues: 50-688; Coverage: 56%)
Gene name: SRPK2
Pfam: Protein kinase domain
InterPro:
CATH:
SRSF protein kinase 2 in PDB entry 2x7g, assembly 1, front view.
SRSF protein kinase 2 in PDB entry 2x7g, assembly 1, side view.
SRSF protein kinase 2 in PDB entry 2x7g, assembly 1, top view.
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