2x6m Summary

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STRUCTURE OF A SINGLE DOMAIN CAMELID ANTIBODY FRAGMENT IN COMPLEX WITH A C-TERMINAL PEPTIDE OF ALPHA-SYNUCLEIN

The structure was published by De Genst, E.J., Guilliams, T., Wellens, J., et al., Steyaert, J., Christodoulou, J., and Dobson, C.M., in 2010 in a paper entitled "Structure and Properties of a Complex of Alpha-Synuclein and a Single-Domain Camelid Antibody." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.62 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY and ALPHA-SYNUCLEIN PEPTIDE.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY Not available
Camelus dromedariussearch Not available 126 100%
B ALPHA-SYNUCLEIN PEPTIDE P37840 (132-140) (SYUA_HUMAN)search Homo sapienssearch 100% 9 66%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37840 (132 - 140) ALPHA-SYNUCLEIN PEPTIDE HOMO SAPIENS

Chain Structural classification (CATH) Sequence family (Pfam)
A Immunoglobulinssearch
B (P37840) PF01387: Synucleinsearch
Chain InterPro annotation
A search Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
B