Function and Biology Details
Reactions catalysed:
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
- 3-hydroxyacyl-CoA dehydrogenase, C-terminal
- 3-hydroxyacyl-CoA dehydrogenase, conserved site
- 3-hydroxyacyl-CoA dehydrogenase, NAD binding
- NAD(P)-binding domain superfamily
- Enoyl-CoA hydratase/isomerase, conserved site
- Enoyl-CoA hydratase/isomerase
- ClpP/crotonase-like domain superfamily
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Peroxisomal bifunctional enzyme (preferred)
PDBe Complex ID:
PDB-CPX-139814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisomal bifunctional enzyme
Molecule details ›
Chains: A, B
Length: 727 amino acids
Theoretical weight: 79.3 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 727 amino acids
Theoretical weight: 79.3 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P07896 (Residues: 1-722; Coverage: 100%)
Sequence domains:
- Enoyl-CoA hydratase/isomerase
- 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
- 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
