2x4f Summary

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The Crystal Structure of the human myosin light chain kinase LOC340156.

A publication describing this structure is not available. The depositing authors are Muniz, J.R.C.search; Mahajan, P.search; Rellos, P.search; Fedorov, O.search; Shrestha, B.search; Wang, J.search; Elkins, J.M.search; Daga, N.search; Cocking, R.search; Chaikuad, A.search; Krojer, T.search; Ugochukwu, E.search; Yue, W.search; Von Delft, F.search; Arrowsmith, C.H.search; Edwards, A.M.search; Weigelt, J.search; Bountra, C.search; Gileadi, O.search; Knapp, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.67 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 Q86YV6 (40-388) (MYLK4_HUMAN)search Homo sapienssearch 90% 373 77%
B MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 Q86YV6 (40-388) (MYLK4_HUMAN)search Homo sapienssearch 90% 373 77%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q86YV6 (40 - 388) MYOSIN LIGHT CHAIN KINASE FAMILY MEMBER 4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q86YV6) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (Q86YV6) nucleotide bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch phosphorylationsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Calcium/calmodulin-dependent/calcium-dependent protein kinasesearch