2wxv Summary

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STRUCTURE OF CDK2-CYCLIN A WITH A PYRAZOLO(4,3-H) QUINAZOLINE-3-CARBOXAMIDE INHIBITOR

The structure was published by Traquandi, G., Ciomei, M., Ballinari, D., et al., Roussel, P., Vulpetti, A., and Brasca, M.G., in 2010 in a paper entitled "Identification of Potent Pyrazolo[4,3-H]Quinazoline-3-Carboxamides as Multi-Cyclin-Dependent Kinase Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2 and CYCLIN-A2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 309 97%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 309 97%
B CYCLIN-A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 265 96%
D CYCLIN-A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 265 96%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (173 - 432) CYCLIN-A2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P24941) ATP bindingsearch protein bindingsearch protein serine/threonine kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch metal ion bindingsearch kinase activitysearch cyclin bindingsearch transferase activitysearch nucleotide bindingsearch histone kinase activitysearch nucleussearch nucleoplasmsearch centrosomesearch cytosolsearch endosomesearch condensed chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch Y chromosomesearch X chromosomesearch cytoskeletonsearch Cajal bodysearch cytoplasmsearch transcription factor complexsearch chromosome, telomeric regionsearch microtubule organizing centersearch mitotic G1 DNA damage checkpointsearch G2/M transition of mitotic cell cyclesearch protein phosphorylationsearch meiotic nuclear divisionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch positive regulation of cell proliferationsearch phosphorylationsearch Ras protein signal transductionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch DNA repairsearch cell cyclesearch positive regulation of transcription, DNA-templatedsearch cell divisionsearch DNA replicationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch potassium ion transportsearch G1/S transition of mitotic cell cyclesearch mitotic nuclear divisionsearch cellular response to DNA damage stimulussearch regulation of gene silencingsearch centrosome duplicationsearch histone phosphorylationsearch positive regulation of DNA-dependent DNA replication initiationsearch blood coagulationsearch mitotic cell cyclesearch cellular response to nitric oxidesearch
B, D (P20248) protein kinase bindingsearch nucleussearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of cell cyclesearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch