2wxk Summary

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THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH INK666.

The structure was published by Berndt, A., Miller, S., Williams, O., et al., Shokat, K.M., Shaw, J.P., and Williams, R.L., in 2010 in a paper entitled "The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM. This molecule has the UniProt identifier O35904 (PK3CD_MOUSE)search. The sample contained 940 residues which is < 90% of the natural sequence. Out of 940 residues 834 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM O35904 (106-504) (PK3CD_MOUSE)search ,
O35904 (505-1043) (PK3CD_MOUSE)search
Mus musculussearch ,
Mus musculussearch
90% ,
90%
940 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O35904 (106 - 504) PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A (O35904) C2- domain Calcium/lipid binding domainsearch, Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4search, Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 5search PF00613: Phosphoinositide 3-kinase family, accessory domain (PIK domain)search, PF00792: Phosphoinositide 3-kinase C2search, PF00794: PI3-kinase family, ras-binding domainsearch, PF02192: PI3-kinase family, p85-binding domainsearch, PF00454: Phosphatidylinositol 3- and 4-kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (O35904) phosphotransferase activity, alcohol group as acceptorsearch transferase activity, transferring phosphorus-containing groupssearch phosphatidylinositol-mediated signalingsearch phosphatidylinositol phosphorylationsearch

Chain InterPro annotation
A C2 domainsearch Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainsearch Phosphatidylinositol 3-/4-kinase, catalytic domainsearch Phosphoinositide 3-kinase, accessory (PIK) domainsearch Phosphatidylinositol 3-kinase, C2 domainsearch Protein kinase-like domainsearch Phosphatidylinositol Kinasesearch Armadillo-type foldsearch Phosphatidylinositol 3/4-kinase, conserved sitesearch Ubiquitin-related domainsearch