2wwp Summary


Crystal structure of the human lipocalin-type prostaglandin D synthase

The structure was published by Lim, S.M., Chen, D., Teo, H., et al., Tresaugues, L., Pervushin, K., and Nordlund, P., in 2013 in a paper entitled "Structural and Dynamic Insights Into Substrate Binding and Catalysis of Human Lipocalin Prostaglandin D Synthase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROSTAGLANDIN-H2 D-ISOMERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROSTAGLANDIN-H2 D-ISOMERASE P41222 (23-190) (PTGDS_HUMAN)search Homo sapienssearch 96% 176 85%
B PROSTAGLANDIN-H2 D-ISOMERASE P41222 (23-190) (PTGDS_HUMAN)search Homo sapienssearch 96% 176 85%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P41222 (23 - 190) PROSTAGLANDIN-H2 D-ISOMERASE Homo sapiens

Chain Sequence family (Pfam)
A, B (P41222) PF00061: Lipocalin / cytosolic fatty-acid binding protein familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P41222) retinoid bindingsearch prostaglandin-D synthase activitysearch transporter activitysearch isomerase activitysearch fatty acid bindingsearch small molecule bindingsearch transportsearch prostaglandin biosynthetic processsearch prostaglandin metabolic processsearch regulation of circadian sleep/wake cycle, sleepsearch lipid metabolic processsearch fatty acid biosynthetic processsearch small molecule metabolic processsearch cyclooxygenase pathwaysearch response to glucocorticoidsearch arachidonic acid metabolic processsearch fatty acid metabolic processsearch rough endoplasmic reticulumsearch nuclear membranesearch extracellular regionsearch membranesearch extracellular vesicular exosomesearch Golgi apparatussearch endoplasmic reticulumsearch perinuclear region of cytoplasmsearch cytoplasmsearch extracellular spacesearch endoplasmic reticulum membranesearch nucleussearch

Chain InterPro annotation
A, B Lipocalin/cytosolic fatty-acid binding domainsearch Lipocalinsearch Prostaglandin D synthasesearch Calycin-likesearch Calycinsearch Lipocalin family conserved sitesearch