› 2wut

X-ray diffraction
1.85Å resolution

Crystal structure of human myelin protein P2 in complex with palmitate

Released:
DOI: 10.2210/pdb2wut/pdb
PDB entry 2wut coloured by chain, front view.
PDB entry 2wut coloured by chain, side view.
PDB entry 2wut coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional characterization of human peripheral nervous system myelin protein P2.
Majava V, Polverini E, Mazzini A, Nanekar R, Knoll W, Peters J, Natali F, Baumgärtel P, Kursula I, Kursula P
PLoS One 5 e10300 (2010)
PMID: 20421974

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136047 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myelin P2 protein Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 14.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02689 (Residues: 1-132; Coverage: 100%)
Gene name: PMP2
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

3 bound ligands:
Ligand PLM 1 x PLM
Ligand CL 1 x CL
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P41212
Unit cell:
a: 66.33Å b: 66.33Å c: 101.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.166 0.209
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The human fatty acid-binding protein family: evolutionary divergences and functions.
Smathers et al. (2011)
4 more

6 mentions without citation

Structural and functional characterization of human peripheral nervous system myelin protein P2.
Majava et al. (2010)
5 more