2wt7 Summary

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Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA

The structure was published by Pogenberg, V., Consani Textor, L., Vanhille, L., Holton, S.J., Sieweke, M.H., and Wilmanns, M., in 2014 in a paper entitled "Design of a bZIP Transcription Factor with Homo/Heterodimer-Induced DNA-Binding Preference." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This entry contains 9 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTO-ONCOGENE PROTEIN C-FOS P01101 (138-200) (FOS_MOUSE)search Mus musculussearch < 90% 63 100%
B TRANSCRIPTION FACTOR MAFB P54841 (214-303) (MAFB_MOUSE)search Mus musculussearch < 90% 90 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01101 (138 - 200) PROTO-ONCOGENE PROTEIN C-FOS Mus musculus
P54841 (214 - 303) TRANSCRIPTION FACTOR MAFB Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch bZIP transcription factorsearch
B bZIP Maf transcription factorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P01101) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch
B (P54841) sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch sequence-specific DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A AP-1 transcription factorsearch Basic-leucine zipper domainsearch
B Basic leucine zipper domain, Maf-typesearch Basic-leucine zipper domainsearch Transcription factor, Skn-1-like, DNA-binding domainsearch Transcription factor Mafsearch Transcription factor MafBsearch