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Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA

X-ray diffraction
2.3Å resolution
PDB entry 2wt7 coloured by chain, front view.
PDB entry 2wt7 coloured by chain, side view.
PDB entry 2wt7 coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transcription factor MafB and Protein c-Fos and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 15641.0 Å2
Buried surface area: 6840.98 Å2
Dissociation area: 1,765.66 Å2
Dissociation energy (ΔGdiss): 30.68 kcal/mol
Dissociation entropy (TΔSdiss): 11.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115914

Macromolecules

Protein c-Fos
Chain: A
Length: 63 amino acids
Theoretical weight: 7.52 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01101 (Residues: 138-200; Coverage: 17%)
Gene name: Fos
Pfam: bZIP transcription factor
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Protein c-Fos in PDB entry 2wt7, assembly 1, front view.
Protein c-Fos in PDB entry 2wt7, assembly 1, side view.
Protein c-Fos in PDB entry 2wt7, assembly 1, top view.
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Transcription factor MafB
Chain: B
Length: 90 amino acids
Theoretical weight: 10.92 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54841 (Residues: 214-303; Coverage: 28%)
Gene names: Krml, Maf1, Mafb
Pfam: bZIP Maf transcription factor
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Transcription factor MafB in PDB entry 2wt7, assembly 1, front view.
Transcription factor MafB in PDB entry 2wt7, assembly 1, side view.
Transcription factor MafB in PDB entry 2wt7, assembly 1, top view.
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DNA chain C
Name: MODIFIED T-MARE MOTIF
Representative chains: C
Length: 16 nucleotides
Theoretical weight: 4.9 KDa
MODIFIED T-MARE MOTIF in PDB entry 2wt7, assembly 1, front view.
MODIFIED T-MARE MOTIF in PDB entry 2wt7, assembly 1, side view.
MODIFIED T-MARE MOTIF in PDB entry 2wt7, assembly 1, top view.
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DNA chain D
Name: MODIFIED T-MARE MOTIF
Representative chains: D
Length: 16 nucleotides
Theoretical weight: 4.9 KDa
MODIFIED T-MARE MOTIF in PDB entry 2wt7, assembly 1, front view.
MODIFIED T-MARE MOTIF in PDB entry 2wt7, assembly 1, side view.
MODIFIED T-MARE MOTIF in PDB entry 2wt7, assembly 1, top view.
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