2wou Summary



The structure was published by Goldberg, F.W., Ward, R.A., Powell, S.J., et al., Gingell, H.J., Wickson, K.F., and Roberts, A.L., in 2009 in a paper entitled "Rapid Generation of a High Quality Lead for Transforming Growth Factor-Beta (Tgf-Beta) Type I Receptor (Alk5)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of TGF-BETA RECEPTOR TYPE-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TGF-BETA RECEPTOR TYPE-1 P36897 (200-503) (TGFR1_HUMAN)search Homo sapienssearch < 90% 306 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P36897 (200 - 503) TGF-BETA RECEPTOR TYPE-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Transforming growth factor beta type I GS-motifsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P36897) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch receptor signaling protein serine/threonine kinase activitysearch protein serine/threonine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A Ser/Thr protein kinase, TGFB receptorsearch Protein kinase domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch