› 2wng

X-ray diffraction
2.49Å resolution

complete extracellular structure of human signal regulatory protein (SIRP) alpha

Released:
DOI: 10.2210/pdb2wng/pdb
PDB entry 2wng coloured by chain, front view.
PDB entry 2wng coloured by chain, side view.
PDB entry 2wng coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of signal-regulatory protein alpha: a link to antigen receptor evolution.
Hatherley D, Graham SC, Harlos K, Stuart DI, Barclay AN
J Biol Chem 284 26613-9 (2009)
PMID: 19628875

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160233 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type substrate 1 Chain: A
Molecule details ›
Chain: A
Length: 327 amino acids
Theoretical weight: 36.2 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P78324 (Residues: 31-350; Coverage: 67%)
Gene names: BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP, SIRPA
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 47.41Å b: 84.37Å c: 98.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.219 0.271
Expression system: Cricetulus griseus

Quick links

Citations

5 review citations

The interaction between signal regulatory protein alpha (SIRPĪ±) and CD47: structure, function, and therapeutic target.
Barclay et al. (2014)
4 more

14 mentions without citation

The landscape overview of CD47-based immunotherapy for hematological malignancies.
Yang et al. (2023)
13 more