2wlw Summary



The structure was published by Price, A.J., Marzetta, F., Lammers, M., et al., Wilson, S.J., Towers, G.J., and James, L.C., in 2009 in a paper entitled "Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PEPTIDYL-PROLYL CIS-TRANS ISOMERASE. This molecule has the UniProt identifier P62940 (PPIA_MACMU)search. The sample contained 165 residues which is 100% of the natural sequence. Out of 165 residues 163 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PEPTIDYL-PROLYL CIS-TRANS ISOMERASE P62940 (1-165) (PPIA_MACMU)search Macaca mulattasearch 100% 165 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62940 (1 - 165) PEPTIDYL-PROLYL CIS-TRANS ISOMERASE Macaca mulatta

Chain Sequence family (Pfam)
A (P62940) PF00160: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLDsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P62940) peptidyl-prolyl cis-trans isomerase activitysearch isomerase activitysearch peptide bindingsearch cytoplasmsearch extracellular regionsearch nucleussearch cytosolsearch protein peptidyl-prolyl isomerizationsearch protein foldingsearch regulation of viral genome replicationsearch

Chain InterPro annotation
A Cyclophilin-type peptidyl-prolyl cis-trans isomerase domainsearch Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved sitesearch Cyclophilin-type peptidyl-prolyl cis-trans isomerasesearch Cyclophilin-like domainsearch