› 2wlw

X-ray diffraction
1.5Å resolution

Structure of the N-terminal capsid domain of HIV-2

Released:
DOI: 10.2210/pdb2wlw/pdb
PDB entry 2wlw coloured by chain, front view.
PDB entry 2wlw coloured by chain, side view.
PDB entry 2wlw coloured by chain, top view.
Source organism: Macaca mulatta
Primary publication:
Active site remodeling switches HIV specificity of antiretroviral TRIMCyp.
Price AJ, Marzetta F, Lammers M, Ylinen LM, Schaller T, Wilson SJ, Towers GJ, James LC
Nat Struct Mol Biol 16 1036-42 (2009)
PMID: 19767750

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase A Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 18.02 KDa
Source organism: Macaca mulatta
Expression system: Escherichia coli
UniProt:
  • Canonical: P62940 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 35.88Å b: 51.12Å c: 75.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.154 0.186
Expression system: Escherichia coli

Quick links

Citations

13 review citations

HIV Restriction Factors and Mechanisms of Evasion.
Malim et al. (2012)
12 more

4 mentions without citation

TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling.
Grütter et al. (2012)
3 more