2whb Summary

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TRUNCATION AND OPTIMISATION OF PEPTIDE INHIBITORS OF CDK2, CYCLIN A THROUGH STRUCTURE GUIDED DESIGN

The structure was published by Kontopidis, G., Andrews, M.J., Mcinnes, C., et al., Renachowski, S., Cowan, A., and Fischer, P.M., in 2009 in a paper entitled "Truncation and Optimisation of Peptide Inhibitors of Cyclin-Dependent Kinase 2-Cyclin a Through Structure-Guided Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, and ARG-ARG-L3O-PFF.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN-A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%
D CYCLIN-A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (173 - 432) CYCLIN-A2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P24941) protein phosphorylationsearch meiotic nuclear divisionsearch mitotic nuclear divisionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch G2/M transition of mitotic cell cyclesearch positive regulation of cell proliferationsearch mitotic cell cyclesearch blood coagulationsearch G1/S transition of mitotic cell cyclesearch DNA replicationsearch positive regulation of DNA-dependent DNA replication initiationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cellular response to DNA damage stimulussearch positive regulation of transcription, DNA-templatedsearch cell cyclesearch histone phosphorylationsearch DNA repairsearch mitotic G1 DNA damage checkpointsearch phosphorylationsearch regulation of gene silencingsearch cell divisionsearch centrosome duplicationsearch potassium ion transportsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cellular response to nitric oxidesearch Ras protein signal transductionsearch ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch metal ion bindingsearch kinase activitysearch histone kinase activitysearch transferase activitysearch cyclin bindingsearch nucleussearch cytosolsearch nucleoplasmsearch X chromosomesearch endosomesearch cytoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch chromosome, telomeric regionsearch Cajal bodysearch Y chromosomesearch cytoskeletonsearch microtubule organizing centersearch centrosomesearch transcription factor complexsearch condensed chromosomesearch
B, D (P20248) regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cell cyclesearch protein kinase bindingsearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch