2wev Summary

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PDB entry 2wev (supersedes 2c5p)

TRUNCATION AND OPTIMISATION OF PEPTIDE INHIBITORS OF CDK2, CYCLIN A THROUGH STRUCTURE GUIDED DESIGN

The structure was published by Kontopidis, G., Andrews, M.J., Mcinnes, C., et al., Renachowski, S., Cowan, A., and Fischer, P.M., in 2009 in a paper entitled "Truncation and Optimisation of Peptide Inhibitors of Cyclin-Dependent Kinase 2-Cyclin a Through Structure-Guided Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, and ARG-ARG-B3L-MEA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN-A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%
D CYCLIN-A2 P20248 (173-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 260 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens
P20248 (173 - 432) CYCLIN-A2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, C (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, D Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P24941) histone kinase activitysearch nucleotide bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch protein bindingsearch ATP bindingsearch kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch cyclin bindingsearch metal ion bindingsearch G1/S transition of mitotic cell cyclesearch G2/M transition of mitotic cell cyclesearch mitotic cell cyclesearch DNA replicationsearch DNA repairsearch protein phosphorylationsearch potassium ion transportsearch cellular response to DNA damage stimulussearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cell cyclesearch mitotic nuclear divisionsearch meiotic nuclear divisionsearch Ras protein signal transductionsearch blood coagulationsearch positive regulation of cell proliferationsearch phosphorylationsearch histone phosphorylationsearch peptidyl-serine phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch mitotic G1 DNA damage checkpointsearch positive regulation of DNA-dependent DNA replication initiationsearch positive regulation of transcription, DNA-templatedsearch centrosome duplicationsearch cell divisionsearch meiotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch regulation of gene silencingsearch cellular response to nitric oxidesearch cyclin-dependent protein kinase holoenzyme complexsearch chromosome, telomeric regionsearch condensed chromosomesearch X chromosomesearch Y chromosomesearch nucleussearch nucleoplasmsearch transcription factor complexsearch cytoplasmsearch endosomesearch centrosomesearch microtubule organizing centersearch cytosolsearch cytoskeletonsearch Cajal bodysearch
B, D (P20248) protein kinase bindingsearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of G2/M transition of mitotic cell cyclesearch regulation of cell cyclesearch nucleussearch

Chain InterPro annotation
A, C Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/F/Osearch Cyclin A, chordatessearch