2weo Summary

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THERMODYNAMIC OPTIMISATION OF CARBONIC ANHYDRASE FRAGMENT INHIBITORS

The structure was published by Scott, A.D., Phillips, C., Alex, A., et al., O'Brien, R., Damian, L., and Jones, L.H., in 2009 in a paper entitled "Thermodynamic Optimisation in Drug Discovery: A Case Study Using Carbonic Anhydrase Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) positive regulation of osteoclast differentiationsearch response to steroid hormonesearch odontogenesis of dentin-containing toothsearch positive regulation of bone resorptionsearch kidney developmentsearch regulation of intracellular pHsearch positive regulation of synaptic transmission, GABAergicsearch morphogenesis of an epitheliumsearch small molecule metabolic processsearch response to zinc ionsearch one-carbon metabolic processsearch angiotensin-activated signaling pathwaysearch bicarbonate transportsearch response to organic substancesearch secretionsearch response to estrogensearch response to pHsearch positive regulation of cellular pH reductionsearch positive regulation of dipeptide transmembrane transportsearch regulation of anion transportsearch regulation of chloride transportsearch cytoplasmsearch cytosolsearch apical part of cellsearch axonsearch extracellular vesicular exosomesearch extracellular spacesearch membranesearch microvillussearch plasma membranesearch basolateral plasma membranesearch myelin sheathsearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch protein bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch