2wd3 Summary



The structure was published by Woo, L.W.L., Jackson, T., Putey, A., et al., Purohit, A., Reed, M.J., and Potter, B.V.L., in 2010 in a paper entitled "Highly Potent First Examples of Dual Aromatase-Steroid Sulfatase Inhibitors Based on a Biphenyl Template." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) positive regulation of cellular pH reductionsearch bicarbonate transportsearch response to organic substancesearch cellular response to fluid shear stresssearch kidney developmentsearch regulation of anion transportsearch small molecule metabolic processsearch regulation of intracellular pHsearch response to estrogensearch one-carbon metabolic processsearch morphogenesis of an epitheliumsearch secretionsearch positive regulation of dipeptide transmembrane transportsearch angiotensin-activated signaling pathwaysearch response to pHsearch odontogenesis of dentin-containing toothsearch positive regulation of synaptic transmission, GABAergicsearch response to steroid hormonesearch response to zinc ionsearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch regulation of chloride transportsearch zinc ion bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch lyase activitysearch protein bindingsearch plasma membranesearch myelin sheathsearch extracellular vesicular exosomesearch cytosolsearch basolateral plasma membranesearch extracellular spacesearch apical part of cellsearch axonsearch microvillussearch membranesearch cytoplasmsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch