2wcf Summary

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CALCIUM-FREE (APO) S100A12

The structure was published by Moroz, O.V., Blagova, E.V., Wilkinson, A.J., Wilson, K.S., and Bronstein, I.B., in 2009 in a paper entitled "The Crystal Structures of Human S100A12 in Apo Form and in Complex with Zinc: New Insights Into S100A12 Oligomerisation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.78 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTEIN S100-A12.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN S100-A12 P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 95 95%
B PROTEIN S100-A12 P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 95 95%
C PROTEIN S100-A12 P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 95 95%
D PROTEIN S100-A12 P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 95 95%
E PROTEIN S100-A12 P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 95 95%
F PROTEIN S100-A12 P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 95 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P80511 (2 - 92) PROTEIN S100-A12 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F (P80511) EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, C, D, E, F (P80511) cytosolsearch cytoplasmsearch nucleussearch cytoskeletonsearch extracellular regionsearch plasma membranesearch membranesearch defense response to bacteriumsearch xenobiotic metabolic processsearch defense response to fungussearch monocyte chemotaxissearch innate immune responsesearch positive regulation of NF-kappaB transcription factor activitysearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch mast cell activationsearch killing of cells of other organismsearch neutrophil chemotaxissearch cytokine secretionsearch positive regulation of inflammatory responsesearch positive regulation of MAP kinase activitysearch inflammatory responsesearch immune system processsearch RAGE receptor bindingsearch calcium ion bindingsearch copper ion bindingsearch metal ion bindingsearch zinc ion bindingsearch protein bindingsearch

Chain InterPro annotation
A, B, C, D, E, F S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch