2waj Summary

pdbe.org/2waj
spacer

CRYSTAL STRUCTURE OF HUMAN JNK3 COMPLEXED WITH A 1-ARYL-3,4-DIHYDROISOQUINOLINE INHIBITOR

The structure was published by Christopher, J.A., Atkinson, F.L., Bax, B.D., et al., Jones, E.J., Mosley, J.E., and Musgrave, J.R., in 2009 in a paper entitled "1-Aryl-3,4-Dihydroisoquinoline Inhibitors of Jnk3." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of MITOGEN-ACTIVATED PROTEIN KINASE 10. This molecule has the UniProt identifier P53779 (MK10_HUMAN)search. The sample contained 364 residues which is < 90% of the natural sequence. Out of 364 residues 346 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MITOGEN-ACTIVATED PROTEIN KINASE 10 P53779 (39-402) (MK10_HUMAN)search Homo sapienssearch 91% 364 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P53779 (39 - 402) MITOGEN-ACTIVATED PROTEIN KINASE 10 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P53779) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P53779) protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, JNKsearch Protein kinase-like domainsearch