2w9z Summary

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CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN

The structure was published by Day, P.J., Cleasby, A., Tickle, I.J., et al., Chopra, R., Lengauer, C., and Jhoti, H., in 2009 in a paper entitled "Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.45 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely G1/S-SPECIFIC CYCLIN-D1 and CELL DIVISION PROTEIN KINASE 4.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A G1/S-SPECIFIC CYCLIN-D1 P24385 (16-271) (CCND1_HUMAN)search Homo sapienssearch 92% 257 95%
B CELL DIVISION PROTEIN KINASE 4 P11802 (1-42) (CDK4_HUMAN)search ,
P11802 (48-303) (CDK4_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
100% ,
100%
306 93%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24385 (16 - 271) G1/S-SPECIFIC CYCLIN-D1 Homo sapiens
P11802 (1 - 42) CELL DIVISION PROTEIN KINASE 4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24385) Cyclin A; domain 1search PF00134: Cyclin, N-terminal domainsearch, PF02984: Cyclin, C-terminal domainsearch
B (P11802) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P24385) nucleussearch cell cyclesearch
B (P11802) protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch

Chain InterPro annotation
A Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/F/Osearch Cyclin Dsearch
B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch