2w96 Summary



The structure was published by Day, P.J., Cleasby, A., Tickle, I.J., et al., Chopra, R., Lengauer, C., and Jhoti, H., in 2009 in a paper entitled "Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely G1/S-SPECIFIC CYCLIN-D1 and CELL DIVISION PROTEIN KINASE 4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A G1/S-SPECIFIC CYCLIN-D1 P24385 (1-271) (CCND1_HUMAN)search Homo sapienssearch 92% 271 91%
P11802 (48-303) (CDK4_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
100% ,
306 87%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24385 (1 - 271) G1/S-SPECIFIC CYCLIN-D1 Homo sapiens
P11802 (1 - 42) CELL DIVISION PROTEIN KINASE 4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24385) Cyclin A; domain 1search PF00134: Cyclin, N-terminal domainsearch, PF02984: Cyclin, C-terminal domainsearch
B (P11802) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P24385) cell cyclesearch response to drugsearch canonical Wnt signaling pathwaysearch negative regulation of transcription from RNA polymerase II promotersearch transcription, DNA-templatedsearch positive regulation of cyclin-dependent protein serine/threonine kinase activitysearch response to steroid hormonesearch Leydig cell differentiationsearch response to X-raysearch mammary gland alveolus developmentsearch re-entry into mitotic cell cyclesearch response to glucocorticoidsearch G1/S transition of mitotic cell cyclesearch response to organonitrogen compoundsearch regulation of cell cyclesearch cellular response to DNA damage stimulussearch cellular response to organic substancesearch negative regulation of cell cycle arrestsearch negative regulation of Wnt signaling pathwaysearch Notch signaling pathwaysearch mitotic G1 DNA damage checkpointsearch response to UV-Asearch negative regulation of epithelial cell differentiationsearch response to estrogensearch positive regulation of G2/M transition of mitotic cell cyclesearch cell divisionsearch response to organic substancesearch positive regulation of cell proliferationsearch response to corticosteronesearch response to magnesium ionsearch regulation of G1/S transition of mitotic cell cyclesearch response to calcium ionsearch response to iron ionsearch regulation of transcription, DNA-templatedsearch positive regulation of protein phosphorylationsearch endoplasmic reticulum unfolded protein responsesearch mitotic cell cyclesearch lactationsearch response to organic cyclic compoundsearch organ regenerationsearch liver developmentsearch mammary gland epithelial cell proliferationsearch fat cell differentiationsearch positive regulation of mammary gland epithelial cell proliferationsearch Wnt signaling pathwaysearch protein phosphorylationsearch response to ethanolsearch response to vitamin Esearch cytoplasmsearch tight junctionsearch cyclin-dependent protein kinase holoenzyme complexsearch nucleoplasmsearch cytosolsearch nucleussearch transcriptional repressor complexsearch membranesearch intracellularsearch nucleolussearch protein bindingsearch histone deacetylase bindingsearch cyclin-dependent protein serine/threonine kinase regulator activitysearch protein kinase bindingsearch kinase activitysearch transcription factor bindingsearch transcription corepressor activitysearch protein complex bindingsearch enzyme bindingsearch proline-rich region bindingsearch protein kinase activitysearch
B (P11802) protein phosphorylationsearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin Dsearch
B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch