2w96 Summary



The structure was published by Day, P.J., Cleasby, A., Tickle, I.J., et al., Chopra, R., Lengauer, C., and Jhoti, H., in 2009 in a paper entitled "Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely G1/S-SPECIFIC CYCLIN-D1 and CELL DIVISION PROTEIN KINASE 4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A G1/S-SPECIFIC CYCLIN-D1 P24385 (1-271) (CCND1_HUMAN)search Homo sapienssearch 92% 271 91%
P11802 (48-303) (CDK4_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
100% ,
306 87%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P24385 (1 - 271) G1/S-SPECIFIC CYCLIN-D1 Homo sapiens
P11802 (1 - 42) CELL DIVISION PROTEIN KINASE 4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24385) Cyclin A; domain 1search PF00134: Cyclin, N-terminal domainsearch, PF02984: Cyclin, C-terminal domainsearch
B (P11802) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24385) regulation of cyclin-dependent protein serine/threonine kinase activitysearch regulation of cell cyclesearch cell cyclesearch transcription, DNA-templatedsearch negative regulation of Wnt signaling pathwaysearch positive regulation of cell proliferationsearch positive regulation of cyclin-dependent protein serine/threonine kinase activitysearch response to calcium ionsearch re-entry into mitotic cell cyclesearch response to iron ionsearch positive regulation of mammary gland epithelial cell proliferationsearch negative regulation of transcription from RNA polymerase II promotersearch response to drugsearch regulation of G1/S transition of mitotic cell cyclesearch cell divisionsearch response to estrogensearch liver developmentsearch response to UV-Asearch positive regulation of G2/M transition of mitotic cell cyclesearch fat cell differentiationsearch organ regenerationsearch negative regulation of cell cycle arrestsearch response to X-raysearch response to ethanolsearch negative regulation of epithelial cell differentiationsearch mitotic G1 DNA damage checkpointsearch response to corticosteronesearch Notch signaling pathwaysearch G1/S transition of mitotic cell cyclesearch mammary gland alveolus developmentsearch mitotic cell cyclesearch regulation of transcription, DNA-templatedsearch canonical Wnt signaling pathwaysearch response to organic substancesearch Leydig cell differentiationsearch response to organic cyclic compoundsearch response to vitamin Esearch cellular response to DNA damage stimulussearch lactationsearch response to organonitrogen compoundsearch protein phosphorylationsearch Wnt signaling pathwaysearch positive regulation of protein phosphorylationsearch mammary gland epithelial cell proliferationsearch response to magnesium ionsearch cellular response to organic substancesearch response to steroid hormonesearch endoplasmic reticulum unfolded protein responsesearch response to glucocorticoidsearch protein kinase bindingsearch kinase activitysearch protein bindingsearch histone deacetylase bindingsearch cyclin-dependent protein serine/threonine kinase regulator activitysearch transcription factor bindingsearch protein complex bindingsearch transcription corepressor activitysearch protein kinase activitysearch enzyme bindingsearch proline-rich region bindingsearch nucleoplasmsearch cytosolsearch nucleussearch membranesearch transcriptional repressor complexsearch cytoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch intracellularsearch nucleolussearch tight junctionsearch
B (P11802) protein phosphorylationsearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch

Chain InterPro annotation
A Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin Dsearch
B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch