2w83 Summary

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CRYSTAL STRUCTURE OF THE ARF6 GTPASE IN COMPLEX WITH A SPECIFIC EFFECTOR, JIP4

The structure was published by Isabet, T., Montagnac, G., Regazzoni, K., et al., Chavrier, P., Houdusse, A., and Menetrey, J., in 2009 in a paper entitled "The Structural Basis of Arf Effector Specificity: The Crystal Structure of Arf6 in a Complex with Jip4." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.93 Å and deposited in 2009.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely ADP-RIBOSYLATION FACTOR 6 and C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ADP-RIBOSYLATION FACTOR 6 P62330 (13-175) (ARF6_HUMAN)search Homo sapienssearch 91% 165 98%
B ADP-RIBOSYLATION FACTOR 6 P62330 (13-175) (ARF6_HUMAN)search Homo sapienssearch 91% 165 98%
E ADP-RIBOSYLATION FACTOR 6 P62330 (13-175) (ARF6_HUMAN)search Homo sapienssearch 91% 165 98%
C C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4 O60271 (406-476) (JIP4_HUMAN)search Homo sapienssearch < 90% 77 87%
D C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4 O60271 (406-476) (JIP4_HUMAN)search Homo sapienssearch < 90% 77 87%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62330 (13 - 175) ADP-RIBOSYLATION FACTOR 6 Homo sapiens
O60271 (406 - 476) C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, E (P62330) P-loop containing nucleotide triphosphate hydrolasessearch PF00025: ADP-ribosylation factor familysearch
C, D arf6 gtpase in complex with a specific effector, jip4search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, E (P62330) GTP bindingsearch protein bindingsearch GTPase activitysearch thioesterase bindingsearch nucleotide bindingsearch small GTPase mediated signal transductionsearch intracellular protein transportsearch protein localization to cell surfacesearch cortical actin cytoskeleton organizationsearch regulation of dendritic spine developmentsearch cell adhesionsearch regulation of filopodium assemblysearch ruffle organizationsearch protein transportsearch regulation of Rac protein signal transductionsearch hepatocyte apoptotic processsearch liver developmentsearch positive regulation of actin filament polymerizationsearch vesicle-mediated transportsearch metabolic processsearch movement of cell or subcellular componentsearch establishment of epithelial cell polaritysearch myeloid cell apoptotic processsearch negative regulation of receptor-mediated endocytosissearch protein localization to endosomesearch nervous system developmentsearch cell differentiationsearch transportsearch cell divisionsearch positive regulation of establishment of protein localization to plasma membranesearch cell cyclesearch intracellularsearch cleavage furrowsearch filopodium membranesearch plasma membranesearch midbodysearch extracellular exosomesearch membranesearch recycling endosomesearch focal adhesionsearch endosomesearch cell cortexsearch cytoplasmsearch Golgi apparatussearch cell projectionsearch recycling endosome membranesearch endocytic vesiclesearch rufflesearch early endosomesearch endosome membranesearch

Chain InterPro annotation
A, B, E Small GTP-binding protein domainsearch Small GTPase superfamily, ARF/SAR typesearch Small GTPase superfamily, ARF typesearch P-loop containing nucleoside triphosphate hydrolasesearch
C, D