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ENHANCING THE RECEPTOR AFFINITY OF THE SIALIC ACID-BINDING DOMAIN OF VIBRIO CHOLERAE SIALIDASE THROUGH MULTIVALENCY

Source organism: Vibrio cholerae
Biochemical function: sialic acid binding
Biological process: not assigned
Cellular component: not assigned

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EC 3.2.1.18: Exo-alpha-sialidase

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Systematic name:
Acetylneuraminyl hydrolase
Alternative Name(s):
  • Acetylneuraminidase
  • Alpha-neuraminidase
  • N-acylneuraminate glycohydrolase
  • Neuraminidase
  • Sialidase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF09264
Domain description: Vibrio cholerae sialidase, lectin insertion
Occurring in:
  1. Sialidase
The deposited structure of PDB entry 2w68 contains 3 copies of Pfam domain PF09264 (Vibrio cholerae sialidase, lectin insertion) in Sialidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015344
Domain description: Vibrio cholerae neuraminidase, lectin-like domain
Occurring in:
  1. Sialidase
IPR013320
Domain description: Concanavalin A-like lectin/glucanase domain superfamily
Occurring in:
  1. Sialidase

Structure domain

CATH CATH domain
2.60.120.200
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Sialidase
The deposited structure of PDB entry 2w68 contains 3 copies of CATH domain 2.60.120.200 (Jelly Rolls) in Sialidase. Showing 1 copy in chain A.

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