2w4o Summary


Crystal structure of Human CAMK4 in complex with 4-Amino(sulfamoyl- phenylamino)-triazole-carbothioic acid (2,6-difluoro-phenyl)-amide)

A publication describing this structure is not available. The depositing authors are Muniz, J.R.C.search; Rellos, P.search; Gileadi, O.search; Fedorov, O.search; Filippakopoulos, P.search; Salah, E.search; Pike, A.search; Phillips, C.search; Niesen, F.search; Shrestha, L.search; Burgess-Brown, N.search; Bullock, A.search; Berridge, G.search; Von Delft, F.search; Edwards, A.M.search; Bountra, C.search; Arrowsmith, C.H.search; Weigelt, J.search; Knapp, S.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.17 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV. This molecule has the UniProt identifier Q16566 (KCC4_HUMAN)search. The sample contained 349 residues which is < 90% of the natural sequence. Out of 349 residues 268 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE IV Q16566 (15-340) (KCC4_HUMAN)search Homo sapienssearch < 90% 349 79%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q16566) protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch