› 2w4o

X-ray diffraction
2.17Å resolution

Crystal structure of Human CAMK4 in complex with 4-Amino(sulfamoyl- phenylamino)-triazole-carbothioic acid (2,6-difluoro-phenyl)-amide)

Released:
DOI: 10.2210/pdb2w4o/pdb
PDB entry 2w4o coloured by chain, front view.
PDB entry 2w4o coloured by chain, side view.
PDB entry 2w4o coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Muniz JRC, Rellos P, Gileadi O, Fedorov O, Filippakopoulos P, Salah E, Pike A, Phillips C, Niesen F, Shrestha L, Burgess-Brown N, Bullock A, Berridge G, von Delft F, Edwards AM, Bountra C, Arrowsmith CH, Weigelt J, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172511 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type IV Chain: A
Molecule details ›
Chain: A
Length: 349 amino acids
Theoretical weight: 39.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q16566 (Residues: 15-340; Coverage: 69%)
Gene names: CAMK, CAMK-GR, CAMK4, CAMKIV
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand DKI 1 x DKI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 42.4Å b: 70.81Å c: 99.151Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.237
Expression system: Escherichia coli BL21

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