› 2w2v

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147253 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related C3 botulinum toxin substrate 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 184 amino acids
Theoretical weight: 20.24 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P15153 (Residues: 1-177; Coverage: 92%)
Gene name: RAC2
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand GTP 4 x GTP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 42.202Å b: 94.529Å c: 107.237Å
α: 90° β: 89.99° γ: 90°
R-values:
R R work R free
0.283 0.28 0.345
Expression system: Spodoptera frugiperda

Quick links

Citations

17 review citations

Phosphoinositides: tiny lipids with giant impact on cell regulation.
Balla T. (2013)
16 more

2 mentions without citation

Computational Equilibrium Thermodynamic and Kinetic Analysis of K-Ras Dimerization through an Effector Binding Surface Suggests Limited Functional Role.
Sayyed-Ahmad et al. (2016)
1 more