2w2c Summary

pdbe.org/2w2c
spacer

STRUCTURE OF THE TETRADECAMERIC OLIGOMERISATION DOMAIN OF CALCIUM-CALMODULIN DEPENDENT PROTEIN KINASE II DELTA

The structure was published by Rellos, P., Pike, A.C.W., Niesen, F.H., et al., Lee, W.H., Von Delft, F., and Knapp, S., in 2010 in a paper entitled "Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 14meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
B CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
C CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
D CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
E CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
F CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
G CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
H CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
I CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
J CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
K CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
L CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
M CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%
N CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Q13557 (334-475) (KCC2D_HUMAN)search Homo sapienssearch < 90% 144 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q13557 (334 - 475) CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J, K, L, M, N Nuclear Transport Factor 2; Chain: A,search Calcium/calmodulin dependent protein kinase II Associationsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C, D, E, F, G, H, I, J, K, L, M, N (Q13557) protein phosphorylationsearch calmodulin-dependent protein kinase activitysearch calmodulin bindingsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J, K, L, M, N Calcium/calmodulin-dependent protein kinase II, association-domainsearch Calcium/calmodulin-dependent/calcium-dependent protein kinasesearch