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Structure of the catalytic domain of the native NanA sialidase from Streptococcus pneumoniae

X-ray diffraction
1.49Å resolution
PDB entry 2w20 coloured by chain, front view.
PDB entry 2w20 coloured by chain, side view.
PDB entry 2w20 coloured by chain, top view.
Source organism: Streptococcus pneumoniae R6
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Sialidase A
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-158649
Assembly 2 (preferred)
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Assembly Name: Sialidase A
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-158649

Macromolecules

Sialidase A
Chains: A, B
Length: 471 amino acids
Theoretical weight: 52.95 KDa
Source organism: Streptococcus pneumoniae R6
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62576 (Residues: 321-791; Coverage: 48%)
Gene names: nanA, spr1536
Pfam: BNR/Asp-box repeat
InterPro:
CATH:
Sialidase A in PDB entry 2w20, assembly 2, front view.
Sialidase A in PDB entry 2w20, assembly 2, side view.
Sialidase A in PDB entry 2w20, assembly 2, top view.
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