2w1g Summary



The structure was published by Howard, S., Berdini, V., Boulstridge, J.A., et al., Williams, G., Vinkovic, M., and Wyatt, P.G., in 2009 in a paper entitled "Fragment-Based Discovery of the Pyrazol-4-Yl Urea (at9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.71 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of SERINE/THREONINE-PROTEIN KINASE 6.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE/THREONINE-PROTEIN KINASE 6 O14965 (122-389) (AURKA_HUMAN)search Homo sapienssearch < 90% 275 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14965 (122 - 389) SERINE/THREONINE-PROTEIN KINASE 6 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (O14965) protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch