2w05 Summary



The structure was published by Anderson, M., Andrews, D.M., Barker, A.J., et al., Tucker, J.A., Walker, M., and Weir, H.M., in 2008 in a paper entitled "Imidazoles: Sar and Development of a Potent Class of Cyclin-Dependent Kinase Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 271 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein kinase activitysearch protein bindingsearch cyclin bindingsearch transferase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch histone kinase activitysearch metal ion bindingsearch nucleotide bindingsearch protein phosphorylationsearch histone phosphorylationsearch phosphorylationsearch DNA repairsearch positive regulation of cell proliferationsearch cellular response to nitric oxidesearch meiotic nuclear divisionsearch potassium ion transportsearch mitotic G1 DNA damage checkpointsearch Ras protein signal transductionsearch positive regulation of transcription, DNA-templatedsearch G2/M transition of mitotic cell cyclesearch mitotic nuclear divisionsearch blood coagulationsearch cell cyclesearch mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cellular response to DNA damage stimulussearch G1/S transition of mitotic cell cyclesearch DNA replicationsearch cell divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch centrosome duplicationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch regulation of gene silencingsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch nucleoplasmsearch transcription factor complexsearch condensed chromosomesearch cytosolsearch Cajal bodysearch endosomesearch cytoskeletonsearch chromosome, telomeric regionsearch cyclin-dependent protein kinase holoenzyme complexsearch microtubule organizing centersearch cytoplasmsearch nucleussearch Y chromosomesearch centrosomesearch X chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch