2vz8 Summary



The structure was published by Maier, T., Leibundgut, M., and Ban, N., in 2008 in a paper entitled "The Crystal Structure of a Mammalian Fatty Acid Synthase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.219 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of FATTY ACID SYNTHASE.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FATTY ACID SYNTHASE A5YV76 (1-2512) (A5YV76_PIG)search Sus scrofasearch 100% 2512 79%
B FATTY ACID SYNTHASE A5YV76 (1-2512) (A5YV76_PIG)search Sus scrofasearch 100% 2512 79%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
A5YV76 (1 - 2512) FATTY ACID SYNTHASE Sus scrofa

Chain Sequence family (Pfam)
A, B (A5YV76) PF00107: Zinc-binding dehydrogenasesearch, PF00109: Beta-ketoacyl synthase, N-terminal domainsearch, PF00550: Phosphopantetheine attachment sitesearch, PF00698: Acyl transferase domainsearch, PF00975: Thioesterase domainsearch, PF02801: Beta-ketoacyl synthase, C-terminal domainsearch, PF08242: Methyltransferase domainsearch, PF08659: KR domainsearch, PF14765: Polyketide synthase dehydratasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (A5YV76) hydrolase activity, acting on ester bondssearch acyl-[acyl-carrier-protein] hydrolase activitysearch catalytic activitysearch enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activitysearch oleoyl-[acyl-carrier-protein] hydrolase activitysearch oxidoreductase activitysearch transferase activitysearch 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activitysearch myristoyl-[acyl-carrier-protein] hydrolase activitysearch nucleotide bindingsearch [acyl-carrier-protein] S-malonyltransferase activitysearch transferase activity, transferring acyl groups other than amino-acyl groupssearch palmitoyl-[acyl-carrier-protein] hydrolase activitysearch fatty acid synthase activitysearch [acyl-carrier-protein] S-acetyltransferase activitysearch 3-oxoacyl-[acyl-carrier-protein] synthase activitysearch 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activitysearch zinc ion bindingsearch metabolic processsearch oxidation-reduction processsearch biosynthetic processsearch

Chain InterPro annotation
A, B Thioesterasesearch Acyl transferase domainsearch Phosphopantetheine attachment sitesearch Acyl carrier protein-likesearch GroES (chaperonin 10)-likesearch Alcohol dehydrogenase, C-terminalsearch Methyltransferase type 12search Polyketide synthase, ketoreductase domainsearch Beta-ketoacyl synthase, N-terminalsearch Beta-ketoacyl synthase, C-terminalsearch Acyl transferasesearch Acyl transferase/acyl hydrolase/lysophospholipasesearch Malonyl-CoA ACP transacylase, ACP-bindingsearch Thiolase-like, subgroupsearch Thiolase-likesearch NAD(P)-binding domainsearch Beta-ketoacyl synthase, active sitesearch search Polyketide synthase, enoylreductasesearch Fatty acid synthase, domain 2search Alpha/Beta hydrolase foldsearch S-adenosyl-L-methionine-dependent methyltransferase-likesearch