EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
The structure was published by Bardelle, C., Cross, D., Davenport, S., et al., Roberts, N.J., Robins, P., and Williams, E.J., in 2008 in a paper entitled "Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of EPHRIN TYPE-B RECEPTOR 4. This molecule has the UniProt identifier P54760 (EPHB4_HUMAN). The sample contained 302 residues which is < 90% of the natural sequence. Out of 302 residues 248 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: