2vwu Summary



The structure was published by Bardelle, C., Cross, D., Davenport, S., et al., Roberts, N.J., Robins, P., and Williams, E.J., in 2008 in a paper entitled "Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of EPHRIN TYPE-B RECEPTOR 4. This molecule has the UniProt identifier P54760 (EPHB4_HUMAN)search. The sample contained 302 residues which is < 90% of the natural sequence. Out of 302 residues 247 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A EPHRIN TYPE-B RECEPTOR 4 P54760 (598-887) (EPHB4_HUMAN)search Homo sapienssearch < 90% 302 83%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P54760 (598 - 887) EPHRIN TYPE-B RECEPTOR 4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch, Ephrin type-A receptor 2 transmembrane domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P54760) protein kinase activitysearch protein tyrosine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch