2vwf Summary

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GRB2 SH3C (2)

The structure was published by Harkiolaki, M., Tsirka, T., Lewitzky, M., et al., Jones, E.Y., O'Reilly, N., and Feller, S.M., in 2009 in a paper entitled "Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the Sh3C Domain of Grb2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.58 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 and GRB2-ASSOCIATED-BINDING PROTEIN 2.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 P62993 (159-214) (GRB2_HUMAN)search Homo sapienssearch 100% 58 96%
B GRB2-ASSOCIATED-BINDING PROTEIN 2 Q9UQC2 (508-522) (GAB2_HUMAN)search Homo sapienssearch < 90% 15 93%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62993 (159 - 214) GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 Homo sapiens
Q9UQC2 (508 - 522) GRB2-ASSOCIATED-BINDING PROTEIN 2 HOMO SAPIENS

Chain Structural classification (CATH) Sequence family (Pfam)
A (P62993) SH3 Domainssearch PF00018: SH3 domainsearch
B
Chain InterPro annotation
A SH3 domainsearch
B