2vv9 Summary

pdbe.org/2vv9
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CDK2 IN COMPLEX WITH AN IMIDAZOLE PIPERAZINE

The structure was published by Finlay, M.R., Acton, D.G., Andrews, D.M., et al., Roberts, A., Tucker, J.A., and Weir, H.M., in 2008 in a paper entitled "Imidazole Piperazines: Sar and Development of a Potent Class of Cyclin-Dependent Kinase Inhibitors with a Novel Binding Mode." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 299 residues which is 100% of the natural sequence. Out of 299 residues 272 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P24941) protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch cyclin bindingsearch nucleotide bindingsearch histone kinase activitysearch metal ion bindingsearch nucleoplasmsearch Y chromosomesearch Cajal bodysearch nucleussearch cytosolsearch X chromosomesearch cytoplasmsearch endosomesearch transcription factor complexsearch chromosome, telomeric regionsearch microtubule organizing centersearch cyclin-dependent protein kinase holoenzyme complexsearch condensed chromosomesearch centrosomesearch cytoskeletonsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch G1/S transition of mitotic cell cyclesearch Ras protein signal transductionsearch cellular response to DNA damage stimulussearch G2/M transition of mitotic cell cyclesearch mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch blood coagulationsearch DNA replicationsearch positive regulation of DNA-dependent DNA replication initiationsearch protein phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch cell divisionsearch positive regulation of cell proliferationsearch meiotic nuclear divisionsearch mitotic G1 DNA damage checkpointsearch centrosome duplicationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch potassium ion transportsearch DNA repairsearch cellular response to nitric oxidesearch cell cyclesearch histone phosphorylationsearch mitotic nuclear divisionsearch regulation of gene silencingsearch phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch