2vv3 Summary


hPPARgamma Ligand binding domain in complex with 4-oxoDHA

The structure was published by Itoh, T., Fairall, L., Amin, K., et al., Nagy, L., Yamamoto, K., and Schwabe, J.W.R., in 2008 in a paper entitled "Structural Basis for the Activation of Ppargamma by Oxidized Fatty Acids." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.85 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA P37231 (232-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 276 93%
B PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA P37231 (232-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 276 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P37231) nucleussearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch