2vuk Summary

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STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO THE STABILIZING SMALL-MOLECULE DRUG PHIKAN083

The structure was published by Boeckler, F.M., Joerger, A.C., Jaggi, G., Rutherford, T.J., Veprintsev, D.B., and Fersht, A.R., in 2008 in a paper entitled "Targeted Rescue of a Destabilized Mutant of P53 by an in Silico Screened Drug." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CELLULAR TUMOR ANTIGEN P53.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELLULAR TUMOR ANTIGEN P53 P04637 (94-312) (P53_HUMAN)search Homo sapienssearch < 90% 219 89%
B CELLULAR TUMOR ANTIGEN P53 P04637 (94-312) (P53_HUMAN)search Homo sapienssearch < 90% 219 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04637 (94 - 312) CELLULAR TUMOR ANTIGEN P53 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Immunoglobulin-likesearch P53 DNA-binding domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P04637) sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch transcription regulatory region DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch apoptotic processsearch

Chain InterPro annotation
A, B p53 tumour suppressor familysearch p53-like transcription factor, DNA-bindingsearch p53, DNA-binding domainsearch p53/RUNT-type transcription factor, DNA-binding domainsearch