2vtm Summary

pdbe.org/2vtm
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IDENTIFICATION OF N-(4-PIPERIDINYL)-4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXAMIDE (AT7519), A NOVEL CYCLIN DEPENDENT KINASE INHIBITOR USING FRAGMENT-BASED X-RAY CRYSTALLOGRAPHY AND STRUCTURE BASED DRUG DESIGN.

The structure was published by Wyatt, P.G., Woodhead, A.J., Berdini, V., et al., Trewartha, G., Walker, M.T., and Woolford, A.J., in 2008 in a paper entitled "Identification of N-(4-Piperidinyl)-4-(2,6-Dichlorobenzoylamino)-1H-Pyrazole-3-Carboxamide (at7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 290 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P24941) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch histone kinase activitysearch nucleotide bindingsearch metal ion bindingsearch kinase activitysearch transferase activitysearch protein phosphorylationsearch mitotic nuclear divisionsearch G1/S transition of mitotic cell cyclesearch phosphorylationsearch DNA repairsearch meiotic nuclear divisionsearch cellular response to DNA damage stimulussearch Ras protein signal transductionsearch cell cyclesearch positive regulation of transcription, DNA-templatedsearch mitotic cell cyclesearch blood coagulationsearch mitotic G2 phasesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch DNA replicationsearch mitotic G1 DNA damage checkpointsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch G2/M transition of mitotic cell cyclesearch regulation of gene silencingsearch cellular response to nitric oxidesearch positive regulation of cell proliferationsearch positive regulation of DNA-dependent DNA replication initiationsearch potassium ion transportsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch histone phosphorylationsearch centrosome duplicationsearch cell divisionsearch nucleoplasmsearch condensed chromosomesearch cytoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch Cajal bodysearch nucleussearch cytosolsearch X chromosomesearch endosomesearch Y chromosomesearch microtubule organizing centersearch centrosomesearch chromosome, telomeric regionsearch transcription factor complexsearch cytoskeletonsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch