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X-ray structure of a conjugate with conduritol-beta-epoxide of acid-beta-glucosidase overexpressed in cultured plant cells

X-ray diffraction
2.15Å resolution
PDB entry 2vt0 coloured by chain, front view.
PDB entry 2vt0 coloured by chain, side view.
PDB entry 2vt0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Lysosomal acid glucosylceramidase
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Multimeric state: monomeric
Accessible surface area: 18737.27 Å2
Buried surface area: 1861.12 Å2
Dissociation area: 59.17 Å2
Dissociation energy (ΔGdiss): 7.58 kcal/mol
Dissociation entropy (TΔSdiss): 0.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137377
Assembly 2
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Assembly Name: Lysosomal acid glucosylceramidase
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Multimeric state: monomeric
Accessible surface area: 18309.62 Å2
Buried surface area: 1420.86 Å2
Dissociation area: 58.25 Å2
Dissociation energy (ΔGdiss): 7.36 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137377

Macromolecules

Lysosomal acid glucosylceramidase
Chains: A, B
Length: 505 amino acids
Theoretical weight: 56.59 KDa
Source organism: Homo sapiens
Expression system: Daucus carota
UniProt:
  • Canonical: P04062 (Residues: 40-536; Coverage: 100%)
Gene names: GBA, GBA1, GC, GLUC
Pfam:
InterPro:
CATH:
SCOP:
Lysosomal acid glucosylceramidase in PDB entry 2vt0, assembly 1, front view.
Lysosomal acid glucosylceramidase in PDB entry 2vt0, assembly 1, side view.
Lysosomal acid glucosylceramidase in PDB entry 2vt0, assembly 1, top view.
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