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EBI PDBe PDBeView

PDBe Entry: 2vrm view

STRUCTURE OF HUMAN MAO B IN COMPLEX WITH PHENYETHYLHYDRAZINE
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.3 Å, R-factor: 20.1%, Free R-factor: 24.6%, Spacegroup: C 2 2 2
Released 22/04/2008, deposition: 09/04/2008, last revision: 24/02/2009
Authors Binda, C.search; Wang, J.search; Li, M.search; Hubalek, F.search; Mattevi, A.search; Edmondson, D.E.search
Primary citation Structural and Mechanistic Studies of Arylalkylhydrazine Inhibition of Human Monoamine Oxidases a and B
BIOCHEMISTRYsearch vol:47, pag:5616-5625 (2008) [PubMed ID 18426226 ]search
Keywords OXIDOREDUCTASEsearch, FADsearch, FLAVINsearch, MEMBRANEsearch, HYDRAZINEsearch, ACETYLATIONsearch, FLAVOPROTEINsearch, MITOCHONDRIONsearch, TRANSMEMBRANEsearch, INHIBITOR BINDINGsearch, MEMBRANE PROTEINsearch, MONOAMINE OXIDASEsearch
EC 1.4.3.4 ExPASy BRENDA search (A B)
Organism Homo sapiens(human) 9606search(A B)
UniProt Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) P27338search (A B)
Solvent A, B
Related entries 2c67, 1oja, 2v5z, 1s3e, 2c73, 1ojb, 2v60, 2byb, 2c65, 2c64, 1oj9, 1ojd, 1s3b, 2c66, 2bk4, 2bk5, 2c70, 1h8r, 2bk3, 2c75, 2v61, 1s2y, 2c72, 1gos, 1s2q, 2c76, 2vrl, 1ojc
Polymers
Id Name Type UniProt Residues Observed
A, B AMINE OXIDASE [FLAVIN-CONTAINING] B Protein P27338 (AOFB_HUMAN)search
 520 95%
Heterogens
Id Name Ligands
A, B FLAVIN-ADENINE DINUCLEOTIDE FAD search
A, B PHENYLETHANE PYL search
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