› 2vrg

Solution NMR

Structure of human MCFD2

Released:
DOI: 10.2210/pdb2vrg/pdb
PDB entry 2vrg coloured by chain, ensemble of 20 models, front view.
PDB entry 2vrg coloured by chain, ensemble of 20 models, side view.
PDB entry 2vrg coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
New insights into multiple coagulation factor deficiency from the solution structure of human MCFD2.
Guy JE, Wigren E, Svärd M, Härd T, Lindqvist Y
J Mol Biol 381 941-55 (2008)
PMID: 18590741

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185565 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Multiple coagulation factor deficiency protein 2 Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 13.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8NI22 (Residues: 23-146; Coverage: 100%)
Gene names: MCFD2, SDNSF
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: AB INITIO SIMULATED ANNEALING IN ARIA2
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Protein sorting receptors in the early secretory pathway.
Dancourt et al. (2010)
5 more

5 mentions without citation

Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII.
Zheng et al. (2010)
4 more