2vqj Summary

pdbe.org/2vqj
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STRUCTURE OF HDAC4 CATALYTIC DOMAIN BOUND TO A TRIFLUOROMETHYLKETONE INHBITOR

The structure was published by Bottomley, M.J., Lo Surdo, P., Di Giovine, P., et al., Steinkuhler, C., Gallinari, P., and Carfi, A., in 2008 in a paper entitled "Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of HISTONE DEACETYLASE 4.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HISTONE DEACETYLASE 4 P56524 (648-1057) (HDAC4_HUMAN)search Homo sapienssearch < 90% 413 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P56524 (648 - 1057) HISTONE DEACETYLASE 4 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Arginase; Chain Asearch Histone deacetylase domainsearch, Arb2 domainsearch
Chain InterPro annotation
A Histone deacetylase superfamilysearch Arb2 domainsearch Histone deacetylase domainsearch