› 2vq6

X-ray diffraction
2.71Å resolution

Torpedo californica acetylcholinesterase complexed with 2-PAM

Released:
DOI: 10.2210/pdb2vq6/pdb
PDB entry 2vq6 coloured by chain, front view.
PDB entry 2vq6 coloured by chain, side view.
PDB entry 2vq6 coloured by chain, top view.
Source organism: Tetronarce californica
Entry authors: Harel M, Silman I, Sussman JL

Function and Biology Details

Reaction catalysed: 
Acetylcholine + H(2)O = choline + acetate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137374 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 543 amino acids
Theoretical weight: 61.33 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P04058 (Residues: 22-564; Coverage: 96%)
Gene name: ache
Sequence domains: Carboxylesterase family
Structure domains: alpha/beta hydrolase

Ligands and Environments

3 bound ligands:
Ligand FP1 1 x FP1
Ligand SO4 1 x SO4
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 113.95Å b: 113.95Å c: 138.05Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.171 0.234

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