Bringing Structure to Biology
wwPDB EMDB
2vpz Summary pdbe.org/2vpz
spacer

PDB entry 2vpz

POLYSULFIDE REDUCTASE NATIVE STRUCTURE

The structure was published by Jormakka, M., Yokoyama, K., Yano, T., et al., Shimamura, T., Curmi, P., and Iwata, S., in 2008 in a paper entitled "Molecular Mechanism of Energy Conservation in Polysulfide Respiration" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely THIOSULFATE REDUCTASE, NRFC PROTEIN, and HYPOTHETICAL MEMBRANE SPANNING PROTEIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A THIOSULFATE REDUCTASE Q72LA4 (1-765) (Q72LA4_THET2)search Thermus thermophilus HB27search 100% 765 96%
E THIOSULFATE REDUCTASE Q72LA4 (1-765) (Q72LA4_THET2)search Thermus thermophilus HB27search 100% 765 96%
B NRFC PROTEIN Q72LA5 (1-195) (Q72LA5_THET2)search Thermus thermophilus HB27search 100% 195 99%
F NRFC PROTEIN Q72LA5 (1-195) (Q72LA5_THET2)search Thermus thermophilus HB27search 100% 195 99%
C HYPOTHETICAL MEMBRANE SPANNING PROTEIN Q72LA6 (1-253) (Q72LA6_THET2)search Thermus thermophilus HB27search 100% 253 99%
G HYPOTHETICAL MEMBRANE SPANNING PROTEIN Q72LA6 (1-253) (Q72LA6_THET2)search Thermus thermophilus HB27search 100% 253 99%

This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q72LA4 (1 - 765) THIOSULFATE REDUCTASE Thermus thermophilus HB27
Q72LA5 (1 - 195) NRFC PROTEIN Thermus thermophilus HB27
Q72LA6 (1 - 253) HYPOTHETICAL MEMBRANE SPANNING PROTEIN Thermus thermophilus HB27

Chain Structural classification (CATH) Sequence family (Pfam)
A, E (Q72LA4) ADC-like domainssearch, Rossmann foldsearch, Dimethylsulfoxide Reductase, domain 2search, Formate dehydrogenase/DMSO reductase,search, Barwin-like endoglucanasessearch Molybdopterin oxidoreductase Fe4S4 domainsearch, Molybdopterin oxidoreductasesearch, Molydopterin dinucleotide binding domainsearch
B, F (Q72LA5) Alpha-Beta Plaitssearch 4Fe-4S binding domainsearch
C, G Formate dehydrogenase/DMSO reductase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, E (Q72LA4) Bindingsearch, Oxidoreductase activitysearch, Molybdenum ion bindingsearch, Metal ion bindingsearch, Iron-sulfur cluster bindingsearch, 4 iron, 4 sulfur cluster bindingsearch Oxidation-reduction processsearch
B, F (Q72LA5) Electron carrier activitysearch, Metal ion bindingsearch, Iron-sulfur cluster bindingsearch, 4 iron, 4 sulfur cluster bindingsearch

Chain InterPro annotation
A, E Twin-arginine translocation pathway, signal sequencesearch, Molybdopterin oxidoreductasesearch, Molydopterin dinucleotide-binding domainsearch, Molybdopterin oxidoreductase, Fe4S4 domainsearch, Aspartate decarboxylase-like foldsearch, Twin-arginine translocation pathway, signal sequence, bacterial/archaealsearch
B, F 7Fe ferredoxinsearch, 4Fe-4S binding domainsearch, 4Fe-4S ferredoxin-type, iron-sulpur binding domainsearch, 4Fe-4S ferredoxin, iron-sulphur binding, conserved sitesearch